Biventricular pacing: more is better!

Oxygen – less is better , more is better ? ?

Altitude training has been employed as a tool for enhancing performance by athletes since the 1964 Mexico Olympics. The cost and impracticality of going to altitude regularly has led to the development of altitude simulation at sea level by creating low oxygen (‘hypoxia’) environments. ‘Altitude’ or ‘hypoxic’ training facilities are now springing up all around the country. The evidence supporti...

Cardiac Resynchronization Therapy; Biventricular Pacing

Although the estimates from limited studies vary on the proportion of patients with heart failure who also have ventricular dyssynchrony as reflected by a prolonged QRS complex, often in the form of left bundle branch block, the number of such patients is large (27% to 53%) and it is certainly in excess of the rate for the general population. Among these patients, 10% to 15% are candidates for ...

Sometimes, more is better.

(See the article by El Sahly et al, on pages 703–12.) Influenza causes significant morbidity and mortality with an estimated 36 000 attributable deaths in the United States annually [1]. Human immunodefi-ciency virus (HIV) infection, specifically , advanced disease (CD4 count ,200 cells/lL), has been associated with excess morbidity and mortality [2]. With the use of combination antiretroviral ...

Is More Entrepreneurship better?

We develop a new perspective on the boundary of the firm that is consistent with the empirical observation that the share of entrepreneurs first decreases and then increases in the course of economic development. Existing theory based on transaction costs (Coase, 1937, and subsequent literature) is difficult to relate to these well-established dynamics. Our approach focuses on changing incentiv...

Is more better?